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Concomitant use or discontinuation of CYP450 isoenzymes including CYP450 3A4 inducers, CYP450 3A4 inhibitors, or CYP450 2D6 inhibitors are complicated; concomitant use demands mindful consideration with the effects over the father or mother drug, tramadol, plus the Energetic metabolite, M1.Codeine Warning: Codeine might be practice-forming; do not